Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016].

gamma-aminobutyric acid type A receptor rho2 subunitMIM:137162Ensembl:ENSG00000111886HGNC:HGNC:4091PA285066q15

GO terms in GABRR2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0034707chloride channel complex
CCIBAGO:0043005neuron projection
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:1902711GABA-A receptor complex
BPIBAGO:0007165signal transduction
BPTASGO:0007165signal transduction
BPIEAGO:0007214gamma-aminobutyric acid signaling pathway
BPIBAGO:0007268chemical synaptic transmission
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0007601visual perception
BPIBAGO:0034220ion transmembrane transport
BPIBAGO:0042391regulation of membrane potential
BPIBAGO:0050877nervous system process
BPIEAGO:1902476chloride transmembrane transport
MFIBAGO:0004890GABA-A receptor activity
MFIBAGO:0005230extracellular ligand-gated ion channel activity
MFIEAGO:0005230extracellular ligand-gated ion channel activity
MFIEAGO:0005254chloride channel activity
MFIEAGO:0019904protein domain specific binding

Gene expression in normal tissue: GABRR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GABRR2

DatabasePathway IDPathway Des.
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP3998Prader-Willi and Angelman Syndrome
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-977442GABA A (rho) receptor activation
reactomeR-HSA-977443GABA receptor activation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GABRR2