SHPRH
Summary: SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
SNF2 histone linker PHD RING helicase | MIM:608048 | Ensembl:ENSG00000146414 | HGNC:HGNC:19336 | PA134880315 | 6q24.3 |
Gene Categories:
DNA REPAIRGO terms in SHPRH
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003677 | DNA binding |
MF | IEA | GO:0004386 | helicase activity |
MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
MF | IEA | GO:0046872 | metal ion binding |
MF | EXP | GO:0061630 | ubiquitin protein ligase activity |
CC | IEA | GO:0000786 | nucleosome |
CC | TAS | GO:0005654 | nucleoplasm |
BP | IDA | GO:0000209 | protein polyubiquitination |
BP | IEA | GO:0006281 | DNA repair |
BP | IEA | GO:0006334 | nucleosome assembly |
BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
BP | TAS | GO:0016567 | protein ubiquitination |
Gene expression in normal tissue: SHPRH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SHPRH
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-8852135 | Protein ubiquitination |
reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in SHPRH