GAK
Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602052 Ensembl IDEnsembl:ENSG00000178950 HGNC IDHGNC:HGNC:4113 PHARMGKB IDPA28528 Map Location4p16.3 |
GO terms in GAK
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0005925 | focal adhesion |
CC | HDA | GO:0016020 | membrane |
CC | IBA | GO:0031982 | vesicle |
Gene expression in normal tissue: GAK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAK
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
reactome | R-HSA-199991 | Membrane Trafficking |
reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in GAK
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |