GAK


Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin G associated kinaseMIM:602052Ensembl:ENSG00000178950HGNC:HGNC:4113PA285284p16.3

GO terms in GAK


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIEAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCIBAGO:0031982vesicle
CCIDAGO:0031982vesicle
CCIBAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0045202synapse
CCIEAGO:0048471perinuclear region of cytoplasm
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0006898receptor-mediated endocytosis
BPIMPGO:0006898receptor-mediated endocytosis
BPISSGO:0007029endoplasmic reticulum organization
BPIMPGO:0007030Golgi organization
BPIEAGO:0007049cell cycle
BPIDAGO:0010977negative regulation of neuron projection development
BPISSGO:0016191synaptic vesicle uncoating
BPIMPGO:0034067protein localization to Golgi apparatus
BPTASGO:0051085chaperone cofactor-dependent protein refolding
BPTASGO:0061024membrane organization
BPIBAGO:0072318clathrin coat disassembly
BPIMPGO:0072318clathrin coat disassembly
BPIBAGO:0072583clathrin-dependent endocytosis
BPIMPGO:0072583clathrin-dependent endocytosis
BPIMPGO:0072659protein localization to plasma membrane
BPIMPGO:0090160Golgi to lysosome transport
BPIMPGO:1905224clathrin-coated pit assembly
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0030276clathrin binding
MFISSGO:0030332cyclin binding
MFTASGO:0051087chaperone binding

Gene expression in normal tissue: GAK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GAK


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus4
iGMDRD116CD4372
iGMDRD560MK-22062
iGMDRD424Tamatinib3
iGMDRD420Leucascandrolide A3
iGMDRD152179324-69-75
iGMDRD318PAC-12
iGMDRD885Compound 1102
iGMDRD870BRD636102
iGMDRD267Oligomycin A3
iGMDRD289Parthenolide2
iGMDRD192CIL561
iGMDRD782DC-45-A22
iGMDRD103SN-383
iGMDRD202Curcumin6
iGMDRD121GMX17786
iGMDRD268Cerulenin3
iGMDRD322FK 8666
iGMDRD506Fedratinib5
iGMDRD329Merck606
iGMDRD871BRD63682

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAK

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