GAK


Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602052
PHARMGKB IDPA28528
Map Location4p16.3

GO terms in GAK


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005794 Golgi apparatus
CC TAS GO:0005829 cytosol
CC IEA GO:0005925 focal adhesion
CC HDA GO:0016020 membrane
CC IBA GO:0031982 vesicle
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Gene expression in normal tissue: GAK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined12Stilbenoid, diarylheptanoid and gingerol biosynthesis1Metabolism1Other, kinases1DNA replication1Apoptosis regulation1PI3K/MTOR signaling1Proteasome1Longevity regulating pathway1Chromatin histone acetylation1

Pathways in GAK


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Database
Pathway ID
Pathway Des.
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2003 miR-targeted genes in leukocytes - TarBase
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
wikipathways WP2005 miR-targeted genes in muscle cell - TarBase
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-199992 trans-Golgi Network Vesicle Budding
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 4
iGMDRD116 CD437 2
iGMDRD560 MK-2206 2
iGMDRD424 Tamatinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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