GAK
Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin G associated kinase | MIM:602052 | Ensembl:ENSG00000178950 | HGNC:HGNC:4113 | PA28528 | 4p16.3 |
GO terms in GAK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0031982 | vesicle |
| CC | IDA | GO:0031982 | vesicle |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0045202 | synapse |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006898 | receptor-mediated endocytosis |
| BP | IMP | GO:0006898 | receptor-mediated endocytosis |
| BP | ISS | GO:0007029 | endoplasmic reticulum organization |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0010977 | negative regulation of neuron projection development |
| BP | ISS | GO:0016191 | synaptic vesicle uncoating |
| BP | IMP | GO:0034067 | protein localization to Golgi apparatus |
| BP | TAS | GO:0051085 | chaperone cofactor-dependent protein refolding |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IBA | GO:0072318 | clathrin coat disassembly |
| BP | IMP | GO:0072318 | clathrin coat disassembly |
| BP | IBA | GO:0072583 | clathrin-dependent endocytosis |
| BP | IMP | GO:0072583 | clathrin-dependent endocytosis |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0090160 | Golgi to lysosome transport |
| BP | IMP | GO:1905224 | clathrin-coated pit assembly |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0030276 | clathrin binding |
| MF | ISS | GO:0030332 | cyclin binding |
| MF | TAS | GO:0051087 | chaperone binding |
Gene expression in normal tissue: GAK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD871 | BRD6368 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAK
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