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DNAJB5

Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameDnaJ heat shock protein family (Hsp40) member B5 OMIM IDMIM:611328 Ensembl IDEnsembl:ENSG00000137094 HGNC IDHGNC:HGNC:14887 PHARMGKB IDPA27417 Map Location9p13.3

GO terms in DNAJB5

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0051082	unfolded protein binding
MF	IEA	GO:0051082	unfolded protein binding
MF	IBA	GO:0051087	chaperone binding
MF	IPI	GO:0051087	chaperone binding
BP	IBA	GO:0000122	negative regulation of transcription by RNA polymerase II

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Gene expression in normal tissue: DNAJB5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DNAJB5

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DNAJB5

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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