DNAJB5
Summary: This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DnaJ heat shock protein family (Hsp40) member B5 | MIM:611328 | Ensembl:ENSG00000137094 | HGNC:HGNC:14887 | PA27417 | 9p13.3 |
GO terms in DNAJB5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0051082 | unfolded protein binding |
| MF | IEA | GO:0051082 | unfolded protein binding |
| MF | IBA | GO:0051087 | chaperone binding |
| MF | IPI | GO:0051087 | chaperone binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006457 | protein folding |
| BP | IEP | GO:0006986 | response to unfolded protein |
| BP | IBA | GO:0051085 | chaperone cofactor-dependent protein refolding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: DNAJB5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNAJB5
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNAJB5
CLASSFICATION
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