TXN2
Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thioredoxin 2 | MIM:609063 | Ensembl:ENSG00000100348 | HGNC:HGNC:17772 | PA38245 | 22q12.3 |
GO terms in TXN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| BP | TAS | GO:0000098 | sulfur amino acid catabolic process |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006662 | glycerol ether metabolic process |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0009725 | response to hormone |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0031669 | cellular response to nutrient levels |
| BP | IEA | GO:0042493 | response to drug |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0048678 | response to axon injury |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
| MF | IEA | GO:0015035 | protein disulfide oxidoreductase activity |
| MF | IEA | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: TXN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TXN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1614558 | Degradation of cysteine and homocysteine |
| reactome | R-HSA-1614635 | Sulfur amino acid metabolism |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP408 | Oxidative Stress |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TXN2
CLASSFICATION
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