TXN2

Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namethioredoxin 2
OMIM IDMIM:609063
Ensembl IDEnsembl:ENSG00000100348
HGNC IDHGNC:HGNC:17772
PHARMGKB IDPA38245
Map Location22q12.3

GO terms in TXN2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005730 nucleolus
CC IDA GO:0005739 mitochondrion
CC TAS GO:0005759 mitochondrial matrix
CC IEA GO:0030425 dendrite
CC IEA GO:0043025 neuronal cell body
BP TAS GO:0000098 sulfur amino acid catabolic process
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Gene expression in normal tissue: TXN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TXN2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1614558 Degradation of cysteine and homocysteine
reactome R-HSA-1614635 Sulfur amino acid metabolism
reactome R-HSA-2262752 Cellular responses to stress
reactome R-HSA-3299685 Detoxification of Reactive Oxygen Species
reactome R-HSA-71291 Metabolism of amino acids and derivatives
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TXN2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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