SULT4A1
Summary: This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
sulfotransferase family 4A member 1 | MIM:608359 | Ensembl:ENSG00000130540 | HGNC:HGNC:14903 | PA412 | 22q13.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SULT4A1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004062 | aryl sulfotransferase activity |
MF | IPI | GO:0005515 | protein binding |
MF | NAS | GO:0008146 | sulfotransferase activity |
MF | IPI | GO:0042802 | identical protein binding |
CC | TAS | GO:0005829 | cytosol |
BP | ND | GO:0008150 | biological_process |
BP | IEA | GO:0008202 | steroid metabolic process |
BP | TAS | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
Gene expression in normal tissue: SULT4A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULT4A1
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP692 | Sulfation Biotransformation Reaction |
wikipathways | WP702 | Metapathway biotransformation Phase I and II |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
reactome | R-HSA-156584 | Cytosolic sulfonation of small molecules |
reactome | R-HSA-211859 | Biological oxidations |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in SULT4A1