SULT4A1
Summary: This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sulfotransferase family 4A member 1 | MIM:608359 | Ensembl:ENSG00000130540 | HGNC:HGNC:14903 | PA412 | 22q13.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SULT4A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004062 | aryl sulfotransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008146 | sulfotransferase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | TAS | GO:0005829 | cytosol |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0008202 | steroid metabolic process |
| BP | TAS | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
Gene expression in normal tissue: SULT4A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULT4A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP692 | Sulfation Biotransformation Reaction |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156584 | Cytosolic sulfonation of small molecules |
| reactome | R-HSA-211859 | Biological oxidations |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SULT4A1
CLASSFICATION
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