GAP43
Summary: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth associated protein 43 | MIM:162060 | Ensembl:ENSG00000172020 | HGNC:HGNC:4140 | PA28553 | 3q13.31 |
GO terms in GAP43
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0031527 | filopodium membrane |
| CC | IEA | GO:0032584 | growth cone membrane |
| BP | TAS | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0009611 | response to wounding |
| BP | IEA | GO:0010001 | glial cell differentiation |
| BP | IEA | GO:0016198 | axon choice point recognition |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IEA | GO:0042246 | tissue regeneration |
| BP | IEA | GO:0045165 | cell fate commitment |
| BP | IDA | GO:0051489 | regulation of filopodium assembly |
| MF | IEA | GO:0001786 | phosphatidylserine binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0035727 | lysophosphatidic acid binding |
| MF | IEA | GO:1901981 | phosphatidylinositol phosphate binding |
Gene expression in normal tissue: GAP43
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAP43
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2276 | Glial Cell Differentiation |
| wikipathways | WP2431 | Spinal Cord Injury |
| pid | ncadherinpathway | N-cadherin signaling events |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAP43
CLASSFICATION
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