Summary: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].

CAP-Gly domain containing linker protein 3MIM:607382Ensembl:ENSG00000105270HGNC:HGNC:24314PA16238243919q13.12

GO terms in CLIP3

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001934positive regulation of protein phosphorylation
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPISSGO:0010828positive regulation of glucose transmembrane transport
BPIMPGO:0018230peptidyl-L-cysteine S-palmitoylation
BPIMPGO:0031115negative regulation of microtubule polymerization
BPIMPGO:0043065positive regulation of apoptotic process
BPIMPGO:0044091membrane biogenesis
BPISSGO:0045444fat cell differentiation
BPIMPGO:0045807positive regulation of endocytosis
BPIMPGO:0072321chaperone-mediated protein transport
BPISSGO:1903078positive regulation of protein localization to plasma membrane
CCIEAGO:0005795Golgi stack
CCISSGO:0005802trans-Golgi network
CCIDAGO:0005886plasma membrane
CCIMPGO:0005886plasma membrane
CCIDAGO:0031901early endosome membrane
CCIDAGO:0032588trans-Golgi network membrane
CCIMPGO:0032588trans-Golgi network membrane
CCIDAGO:0045121membrane raft
CCIDAGO:0055038recycling endosome membrane
MFIPIGO:0005515protein binding
MFIDAGO:0008017microtubule binding
MFIMPGO:0008017microtubule binding
MFIDAGO:0035594ganglioside binding

Gene expression in normal tissue: CLIP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLIP3

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLIP3