ACOT11
Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606803 Ensembl IDEnsembl:ENSG00000162390 HGNC IDHGNC:HGNC:18156 PHARMGKB IDPA38303 Map Location1p32.3 | |||||
GO terms in ACOT11
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000062 | fatty-acyl-CoA binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IBA | GO:0016290 | palmitoyl-CoA hydrolase activity |
| MF | IBA | GO:0036042 | long-chain fatty acyl-CoA binding |
| MF | IBA | GO:0047617 | acyl-CoA hydrolase activity |
| MF | TAS | GO:0047617 | acyl-CoA hydrolase activity |
Gene expression in normal tissue: ACOT11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACOT11
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACOT11
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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