ACOT11
Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| acyl-CoA thioesterase 11 | MIM:606803 | Ensembl:ENSG00000162390 | HGNC:HGNC:18156 | PA38303 | 1p32.3 |
GO terms in ACOT11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000062 | fatty-acyl-CoA binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IBA | GO:0016290 | palmitoyl-CoA hydrolase activity |
| MF | IBA | GO:0036042 | long-chain fatty acyl-CoA binding |
| MF | IBA | GO:0047617 | acyl-CoA hydrolase activity |
| MF | TAS | GO:0047617 | acyl-CoA hydrolase activity |
| MF | IEA | GO:0052689 | carboxylic ester hydrolase activity |
| BP | IBA | GO:0006631 | fatty acid metabolic process |
| BP | NAS | GO:0006631 | fatty acid metabolic process |
| BP | IBA | GO:0006637 | acyl-CoA metabolic process |
| BP | TAS | GO:0006637 | acyl-CoA metabolic process |
| BP | ISS | GO:0009266 | response to temperature stimulus |
| BP | IBA | GO:0009409 | response to cold |
| BP | ISS | GO:0009409 | response to cold |
| BP | NAS | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:1900535 | palmitic acid biosynthetic process |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ACOT11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACOT11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACOT11
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