PPP1R16B


Summary: The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015].

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Ensembl ID
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Gene Categories:

PROTEIN PHOSPHATASE

GO terms in PPP1R16B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0019888 protein phosphatase regulator activity
BP IMP GO:0001938 positive regulation of endothelial cell proliferation
BP IMP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
BP IMP GO:0035304 regulation of protein dephosphorylation
BP IDA GO:0035307 positive regulation of protein dephosphorylation
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Gene expression in normal tissue: PPP1R16B

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1Protein stability and degradation1

Pathways in PPP1R16B


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP1R16B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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