PPP1R16B
Summary: The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 1 regulatory subunit 16B | MIM:613275 | Ensembl:ENSG00000101445 | HGNC:HGNC:15850 | PA33635 | 20q11.23 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PPP1R16B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019888 | protein phosphatase regulator activity |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IMP | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0035304 | regulation of protein dephosphorylation |
| BP | IDA | GO:0035307 | positive regulation of protein dephosphorylation |
| BP | IDA | GO:0035308 | negative regulation of protein dephosphorylation |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| BP | ISS | GO:0051489 | regulation of filopodium assembly |
| BP | IMP | GO:0061028 | establishment of endothelial barrier |
| BP | IMP | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation |
| BP | IMP | GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0042995 | cell projection |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: PPP1R16B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R16B
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R16B
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