ABCA12


Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

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GO terms in ABCA12


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006869 lipid transport
BP IDA GO:0006869 lipid transport
BP NAS GO:0006869 lipid transport
BP IDA GO:0010875 positive regulation of cholesterol efflux
BP NAS GO:0019725 cellular homeostasis
BP IEA GO:0031424 keratinization
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Gene expression in normal tissue: ABCA12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCA12


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Database
Pathway ID
Pathway Des.
kegg hsa02010 ABC transporters - Homo sapiens (human)
reactome R-HSA-1369062 ABC transporters in lipid homeostasis
reactome R-HSA-1643685 Disease
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-382556 ABC-family proteins mediated transport
reactome R-HSA-5619084 ABC transporter disorders
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCA12

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Model
Level
Reference ID
Tissue
Cancer
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Clinical Response
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