ABCA12
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607800 Ensembl IDEnsembl:ENSG00000144452 HGNC IDHGNC:HGNC:14637 PHARMGKB IDPA29604 Map Location2q35 | |||||
GO terms in ABCA12
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006869 | lipid transport |
| BP | IDA | GO:0006869 | lipid transport |
| BP | NAS | GO:0006869 | lipid transport |
| BP | IDA | GO:0010875 | positive regulation of cholesterol efflux |
| BP | NAS | GO:0019725 | cellular homeostasis |
| BP | IEA | GO:0031424 | keratinization |
Gene expression in normal tissue: ABCA12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCA12
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| reactome | R-HSA-1369062 | ABC transporters in lipid homeostasis |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-5619084 | ABC transporter disorders |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCA12
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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