STEAP2


Summary: This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605094
PHARMGKB IDPA38473
Map Location7q21.13

Gene Categories:

TRANSPORTER

GO terms in STEAP2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006893 Golgi to plasma membrane transport
BP IDA GO:0006897 endocytosis
BP IDA GO:0009725 response to hormone
BP IBA GO:0015677 copper ion import
BP IDA GO:0045055 regulated exocytosis
BP IEA GO:0055072 iron ion homeostasis
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Gene expression in normal tissue: STEAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STEAP2


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Database
Pathway ID
Pathway Des.
wikipathways WP3286 Copper homeostasis
kegg hsa04978 Mineral absorption - Homo sapiens (human)
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-917937 Iron uptake and transport
reactome R-HSA-917977 Transferrin endocytosis and recycling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STEAP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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