GAS6
Summary: This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth arrest specific 6 | MIM:600441 | Ensembl:ENSG00000183087 | HGNC:HGNC:4168 | PA28582 | 13q34 |
GO terms in GAS6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IDA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IDA | GO:0005245 | voltage-gated calcium channel activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0030296 | protein tyrosine kinase activator activity |
| MF | IPI | GO:0030971 | receptor tyrosine kinase binding |
| MF | IDA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IDA | GO:0048018 | receptor ligand activity |
| MF | IDA | GO:0060090 | molecular adaptor activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001961 | positive regulation of cytokine-mediated signaling pathway |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | ISS | GO:0003104 | positive regulation of glomerular filtration |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IDA | GO:0006909 | phagocytosis |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IDA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007167 | enzyme linked receptor protein signaling pathway |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0009267 | cellular response to starvation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0010934 | macrophage cytokine production |
| BP | TAS | GO:0016477 | cell migration |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0019064 | fusion of virus membrane with host plasma membrane |
| BP | IDA | GO:0019079 | viral genome replication |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0031589 | cell-substrate adhesion |
| BP | ISS | GO:0032008 | positive regulation of TOR signaling |
| BP | ISS | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IDA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IDA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0033159 | negative regulation of protein import into nucleus, translocation |
| BP | IDA | GO:0035457 | cellular response to interferon-alpha |
| BP | IDA | GO:0035690 | cellular response to drug |
| BP | IDA | GO:0035754 | B cell chemotaxis |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0043277 | apoptotic cell clearance |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0043491 | protein kinase B signaling |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0046813 | receptor-mediated virion attachment to host cell |
| BP | IDA | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IDA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IDA | GO:0050711 | negative regulation of interleukin-1 secretion |
| BP | IDA | GO:0050766 | positive regulation of phagocytosis |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | IDA | GO:0070168 | negative regulation of biomineral tissue development |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | TAS | GO:0070527 | platelet aggregation |
| BP | IDA | GO:0070588 | calcium ion transmembrane transport |
| BP | IDA | GO:0071307 | cellular response to vitamin K |
| BP | ISS | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IDA | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0085029 | extracellular matrix assembly |
| BP | IEP | GO:0097028 | dendritic cell differentiation |
| BP | IDA | GO:0097241 | hematopoietic stem cell migration to bone marrow |
| BP | IDA | GO:1900142 | negative regulation of oligodendrocyte apoptotic process |
| BP | IDA | GO:1900165 | negative regulation of interleukin-6 secretion |
| BP | IDA | GO:2000270 | negative regulation of fibroblast apoptotic process |
| BP | IDA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| BP | IDA | GO:2000510 | positive regulation of dendritic cell chemotaxis |
| BP | ISS | GO:2000533 | negative regulation of renal albumin absorption |
| BP | IDA | GO:2000669 | negative regulation of dendritic cell apoptotic process |
Gene expression in normal tissue: GAS6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAS6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pharmgkb | PA145011114 | Warfarin Pathway, Pharmacodynamics |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-159740 | Gamma-carboxylation of protein precursors |
| reactome | R-HSA-159763 | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
| reactome | R-HSA-159782 | Removal of aminoterminal propeptides from gamma-carboxylated proteins |
| reactome | R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| reactome | R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAS6
CLASSFICATION
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