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GAS6

Summary: This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namegrowth arrest specific 6 OMIM IDMIM:600441 Ensembl IDEnsembl:ENSG00000183087 HGNC IDHGNC:HGNC:4168 PHARMGKB IDPA28582 Map Location13q34

Gene Categories:

PROTEASE INHIBITOR TRANSPORTER DRUGGABLE GENOME ION CHANNEL PROTEASE KINASE TUMOR SUPPRESSOR DRUG RESISTANCE TYROSINE KINASE

GO terms in GAS6

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0001786	phosphatidylserine binding
MF	IDA	GO:0005102	signaling receptor binding
MF	IPI	GO:0005102	signaling receptor binding
MF	IDA	GO:0005245	voltage-gated calcium channel activity
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding

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Gene expression in normal tissue: GAS6

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GAS6

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Database	Pathway ID	Pathway Des.
wikipathways	WP4180	Ebola Virus Pathway on Host
wikipathways	WP4217	Ebola Virus Pathway on Host
pharmgkb	PA145011114	Warfarin Pathway, Pharmacodynamics
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-159740	Gamma-carboxylation of protein precursors

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD117	Docetaxel	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAS6

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.