FBXO10


Summary: Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
F-box protein 10MIM:609092Ensembl:ENSG00000256966HGNC:HGNC:13589PA280309p13.2

Gene Categories:

METHYL TRANSFERASE

GO terms in FBXO10


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004842ubiquitin-protein transferase activity
MFNASGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
BPTASGO:0000209protein polyubiquitination
BPIMPGO:0006511ubiquitin-dependent protein catabolic process
BPIEAGO:0006915apoptotic process
BPNASGO:0016567protein ubiquitination
BPIMPGO:0042981regulation of apoptotic process
BPTASGO:0043687post-translational protein modification
CCNASGO:0000151ubiquitin ligase complex
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: FBXO10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBXO10


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBXO10

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