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GATA6

Summary: This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
GATA binding protein 6	MIM:601656	Ensembl:ENSG00000141448	HGNC:HGNC:4174	PA28589	18q11.2

Gene Categories:

DRUG RESISTANCE TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR

GO terms in GATA6

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0001701	in utero embryonic development
BP	IEA	GO:0001889	liver development
BP	IMP	GO:0003148	outflow tract septum morphogenesis
BP	IEA	GO:0003309	type B pancreatic cell differentiation
BP	IEA	GO:0003310	pancreatic A cell differentiation
BP	IDA	GO:0006366	transcription by RNA polymerase II
BP	IEA	GO:0006644	phospholipid metabolic process
BP	IEA	GO:0007493	endodermal cell fate determination
BP	IBA	GO:0007507	heart development
BP	TAS	GO:0007596	blood coagulation
BP	IEP	GO:0008584	male gonad development
BP	IBA	GO:0009887	animal organ morphogenesis
BP	IBA	GO:0009888	tissue development
BP	IEA	GO:0014898	cardiac muscle hypertrophy in response to stress
BP	IBA	GO:0030513	positive regulation of BMP signaling pathway
BP	IMP	GO:0032911	negative regulation of transforming growth factor beta1 production
BP	IMP	GO:0032912	negative regulation of transforming growth factor beta2 production
BP	IEA	GO:0035239	tube morphogenesis
BP	IMP	GO:0042493	response to drug
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043627	response to estrogen
BP	TAS	GO:0044267	cellular protein metabolic process
BP	IBA	GO:0045165	cell fate commitment
BP	IDA	GO:0045766	positive regulation of angiogenesis
BP	IDA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IBA	GO:0048468	cell development
BP	IBA	GO:0048565	digestive tract development
BP	IEA	GO:0048645	animal organ formation
BP	IBA	GO:0048646	anatomical structure formation involved in morphogenesis
BP	IMP	GO:0051145	smooth muscle cell differentiation
BP	IEA	GO:0051891	positive regulation of cardioblast differentiation
BP	IEA	GO:0055007	cardiac muscle cell differentiation
BP	IEA	GO:0060045	positive regulation of cardiac muscle cell proliferation
BP	IEA	GO:0060430	lung saccule development
BP	IEA	GO:0060486	Clara cell differentiation
BP	IEA	GO:0060510	type II pneumocyte differentiation
BP	IDA	GO:0060575	intestinal epithelial cell differentiation
BP	IMP	GO:0060947	cardiac vascular smooth muscle cell differentiation
BP	IDA	GO:0070848	response to growth factor
BP	IDA	GO:0071158	positive regulation of cell cycle arrest
BP	IEA	GO:0071371	cellular response to gonadotropin stimulus
BP	IDA	GO:0071456	cellular response to hypoxia
BP	IEA	GO:0071773	cellular response to BMP stimulus
BP	IDA	GO:0110024	positive regulation of cardiac muscle myoblast proliferation
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0031965	nuclear membrane
MF	IBA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IMP	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IBA	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding
MF	IBA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IEA	GO:0001103	RNA polymerase II repressing transcription factor binding
MF	IBA	GO:0003700	DNA-binding transcription factor activity
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IEA	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008134	transcription factor binding
MF	IEA	GO:0008270	zinc ion binding
MF	IPI	GO:0019901	protein kinase binding
MF	IDA	GO:0044212	transcription regulatory region DNA binding

Gene expression in normal tissue: GATA6

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA6

Database	Pathway ID	Pathway Des.
wikipathways	WP1591	Heart Development
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP2858	Ectoderm Differentiation
wikipathways	WP3382	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
pid	hes_heypathway	Notch-mediated HES/HEY network
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-5683826	Surfactant metabolism
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD442	BMS-509744	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA6

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DATATYPES

CLASSFICATION

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