GATA6

Summary: This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameGATA binding protein 6
OMIM IDMIM:601656
Ensembl IDEnsembl:ENSG00000141448
HGNC IDHGNC:HGNC:4174
PHARMGKB IDPA28589
Map Location18q11.2

GO terms in GATA6


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001701 in utero embryonic development
BP IEA GO:0001889 liver development
BP IMP GO:0003148 outflow tract septum morphogenesis
BP IEA GO:0003309 type B pancreatic cell differentiation
BP IEA GO:0003310 pancreatic A cell differentiation
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Gene expression in normal tissue: GATA6

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Pathways in GATA6


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Database
Pathway ID
Pathway Des.
wikipathways WP1591 Heart Development
wikipathways WP2853 Endoderm Differentiation
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP2858 Ectoderm Differentiation
wikipathways WP3382 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
pid hes_heypathway Notch-mediated HES/HEY network
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD442 BMS-509744 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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