FBXO5
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| F-box protein 5 | MIM:606013 | Ensembl:ENSG00000112029 | HGNC:HGNC:13584 | PA28045 | 6q25.2 |
Gene Categories:
TUMOR SUPPRESSORGO terms in FBXO5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:1990948 | ubiquitin ligase inhibitor activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0001556 | oocyte maturation |
| BP | IEA | GO:0007057 | spindle assembly involved in female meiosis I |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | ISS | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0016050 | vesicle organization |
| BP | IBA | GO:0045835 | negative regulation of meiotic nuclear division |
| BP | IEA | GO:0046785 | microtubule polymerization |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:1904667 | negative regulation of ubiquitin protein ligase activity |
Gene expression in normal tissue: FBXO5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FBXO5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176417 | Phosphorylation of Emi1 |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-68881 | Mitotic Metaphase/Anaphase Transition |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| pid | plk1_pathway | PLK1 signaling events |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FBXO5
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