KAT2A
Summary: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine acetyltransferase 2A | MIM:602301 | Ensembl:ENSG00000108773 | HGNC:HGNC:4201 | PA162392664 | 17q21.2 |
GO terms in KAT2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | ISS | GO:0001816 | cytokine production |
| BP | IEA | GO:0001843 | neural tube closure |
| BP | TAS | GO:0006338 | chromatin remodeling |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | ISS | GO:0007507 | heart development |
| BP | ISS | GO:0007616 | long-term memory |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016578 | histone deubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0018393 | internal peptidyl-lysine acetylation |
| BP | IEA | GO:0021537 | telencephalon development |
| BP | IEA | GO:0022037 | metencephalon development |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IEA | GO:0031346 | positive regulation of cell projection organization |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IEA | GO:0031667 | response to nutrient levels |
| BP | IEA | GO:0035066 | positive regulation of histone acetylation |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | IEA | GO:0043983 | histone H4-K12 acetylation |
| BP | IEA | GO:0044154 | histone H3-K14 acetylation |
| BP | ISS | GO:0045589 | regulation of regulatory T cell differentiation |
| BP | TAS | GO:0045815 | positive regulation of gene expression, epigenetic |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046600 | negative regulation of centriole replication |
| BP | ISS | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0048312 | intracellular distribution of mitochondria |
| BP | ISS | GO:0050863 | regulation of T cell activation |
| BP | IEA | GO:0055007 | cardiac muscle cell differentiation |
| BP | ISS | GO:0060173 | limb development |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071929 | alpha-tubulin acetylation |
| BP | IDA | GO:0106077 | histone succinylation |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | IEA | GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| CC | IEA | GO:0000790 | nuclear chromatin |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0030914 | STAGA complex |
| CC | IDA | GO:0033276 | transcription factor TFTC complex |
| CC | IDA | GO:0045252 | oxoglutarate dehydrogenase complex |
| CC | IEA | GO:0072686 | mitotic spindle |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | TAS | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0010484 | H3 histone acetyltransferase activity |
| MF | IEA | GO:0019903 | protein phosphatase binding |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IEA | GO:0043997 | histone acetyltransferase activity (H4-K12 specific) |
| MF | IDA | GO:0061733 | peptide-lysine-N-acetyltransferase activity |
| MF | IDA | GO:0106078 | histone succinyltransferase activity |
Gene expression in normal tissue: KAT2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KAT2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP4242 | Notch Signaling Pathway |
| pid | e2f_pathway | E2F transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | myc_pathway | C-MYC pathway |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250924 | B-WICH complex positively regulates rRNA expression |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD321 | Daporinad | 1 |
| iGMDRD614 | Dabrafenib | 1 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD50 | Cytarabine | 2 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD317 | CCT 018159 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD88 | AICA ribonucleotide | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD173 | Epothilone B | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD421 | AZD7762 | 2 |
| iGMDRD377 | Compound 1b | 1 |
| iGMDRD63 | Camptothecin | 2 |
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD378 | ZM-447439 | 2 |
| iGMDRD253 | Vincaleukoblastine | 2 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD66 | Doxorubicin | 2 |
| iGMDRD700 | AUY922 | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD391 | OSU-03012 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KAT2A
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.