KAT2A

Summary: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namelysine acetyltransferase 2A
OMIM IDMIM:602301
Ensembl IDEnsembl:ENSG00000108773
HGNC IDHGNC:HGNC:4201
PHARMGKB IDPA162392664
Map Location17q21.2

GO terms in KAT2A


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001701 in utero embryonic development
BP IEA GO:0001756 somitogenesis
BP ISS GO:0001816 cytokine production
BP IEA GO:0001843 neural tube closure
BP TAS GO:0006338 chromatin remodeling
BP TAS GO:0006357 regulation of transcription by RNA polymerase II
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Gene expression in normal tissue: KAT2A

Gene-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 8undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 32BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 8

Gene-drug pathway distribution

undefined15DNA replication5Mitosis4Cell cycle3Protein stability and degradation3Metabolism2Other, kinases2Biosynthesis of alkaloids derived from shikimate pathway1Bile secretion1Chromatin histone acetylation1

Pathways in KAT2A


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Database
Pathway ID
Pathway Des.
wikipathways WP268 Notch Signaling Pathway
wikipathways WP4242 Notch Signaling Pathway
pid e2f_pathway E2F transcription factor network
pid myc_activpathway Validated targets of C-MYC transcriptional activation
pid myc_pathway C-MYC pathway
pid p53downstreampathway Direct p53 effectors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD160 Cis-Platin 1
iGMDRD321 Daporinad 1
iGMDRD614 Dabrafenib 1
iGMDRD116 CD437 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KAT2A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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