Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014].

olfactory receptor family 8 subfamily G member 1 (gene/pseudogene)Ensembl:ENSG00000197849HGNC:HGNC:8484PA3276411q24.2

GO terms in OR8G1

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007608sensory perception of smell
BPNASGO:0007608sensory perception of smell
BPIEAGO:0050911detection of chemical stimulus involved in sensory perception of smell
CCTASGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
MFIEAGO:0004930G-protein coupled receptor activity
MFIBAGO:0004984olfactory receptor activity
MFNASGO:0004984olfactory receptor activity
MFIBAGO:0005549odorant binding

Gene expression in normal tissue: OR8G1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OR8G1

DatabasePathway IDPathway Des.
kegghsa04740Olfactory transduction - Homo sapiens (human)
wikipathwaysWP117GPCRs, Other
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-381753Olfactory Signaling Pathway
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OR8G1