OR8G1
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| olfactory receptor family 8 subfamily G member 1 (gene/pseudogene) | Ensembl:ENSG00000197849 | HGNC:HGNC:8484 | PA32764 | 11q24.2 |
GO terms in OR8G1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007608 | sensory perception of smell |
| BP | NAS | GO:0007608 | sensory perception of smell |
| BP | IEA | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IBA | GO:0004984 | olfactory receptor activity |
| MF | NAS | GO:0004984 | olfactory receptor activity |
| MF | IBA | GO:0005549 | odorant binding |
Gene expression in normal tissue: OR8G1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OR8G1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| wikipathways | WP117 | GPCRs, Other |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-381753 | Olfactory Signaling Pathway |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OR8G1
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