PLEK2

Summary: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepleckstrin 2
OMIM IDMIM:608007
Ensembl IDEnsembl:ENSG00000100558
HGNC IDHGNC:HGNC:19238
PHARMGKB IDPA134963543
Map Location14q23.3-q24.1

GO terms in PLEK2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0030036 actin cytoskeleton organization
BP IEA GO:0031346 positive regulation of cell projection organization
BP IEA GO:0035556 intracellular signal transduction
CC IEA GO:0005737 cytoplasm
CC IEA GO:0005856 cytoskeleton
CC IEA GO:0031258 lamellipodium membrane
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Gene expression in normal tissue: PLEK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLEK2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLEK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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