LATS2


Summary: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
large tumor suppressor kinase 2MIM:604861Ensembl:ENSG00000150457HGNC:HGNC:6515PA3030213q12.11

GO terms in LATS2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
BPIBAGO:0000082G1/S transition of mitotic cell cycle
BPIDAGO:0000082G1/S transition of mitotic cell cycle
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0009755hormone-mediated signaling pathway
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIBAGO:0035329hippo signaling
BPIDAGO:0035329hippo signaling
BPTASGO:0035329hippo signaling
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIBAGO:0043065positive regulation of apoptotic process
BPIDAGO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0046620regulation of organ growth
BPIEAGO:0051301cell division
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
CCIBAGO:0000922spindle pole
CCIDAGO:0000922spindle pole
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol

Gene expression in normal tissue: LATS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LATS2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2028269Signaling by Hippo
pidar_pathwayCoregulation of Androgen receptor activity
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
wikipathwaysWP4239EMT transition in Colorectal Cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD484Pluripotin3
iGMDRD546BMS-7548071
iGMDRD387CHIR-990212
iGMDRD1008SR-II-138A1
iGMDRD579PF7507
iGMDRD126Tipifarnib5
iGMDRD433Lexibulin2
iGMDRD634SCHEMBL26080415
iGMDRD679Bistramide A3
iGMDRD466Chaetocin1
iGMDRD639YK 4-2793
iGMDRD193Fqi14
iGMDRD446LY 21832406
iGMDRD441TW 373
iGMDRD187BRD98765
iGMDRD8024-methylfasudil3
iGMDRD255SB2250022
iGMDRD138PX 121
iGMDRD356PNU-746541
iGMDRD451Serdemetan2
iGMDRD64Parbendazole4
iGMDRD369TGX-1151
iGMDRD60Quinoclamine5
iGMDRD506Fedratinib2
iGMDRD888Compound 441
iGMDRD100Zebularine3
iGMDRD399Selumetinib3
iGMDRD74Idarubicin2
iGMDRD523Cyanoquinoline, 112
iGMDRD405PIK-751
iGMDRD424Tamatinib2
iGMDRD154NSC237665
iGMDRD901ELCPK1
iGMDRD123Isoevodiamine3
iGMDRD351GW843682X5
iGMDRD314Tanespimycin1
iGMDRD341Triacsin c2
iGMDRD481Dactolisib2
iGMDRD77Itraconazole3
iGMDRD267Oligomycin A3
iGMDRD705Nakiterpiosin3
iGMDRD6AM-5805
iGMDRD434BMS-5369241
iGMDRD158NSC1415404
iGMDRD121GMX17782
iGMDRD322FK 8662
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib2
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD367Ro 28-16755
iGMDRD872BRD71376

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LATS2

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