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STEAP1

Summary: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
STEAP family member 1	MIM:604415	Ensembl:ENSG00000164647	HGNC:HGNC:11378	PA36193	7q21.13

Gene Categories:

DRUGGABLE GENOME TRANSPORTER

GO terms in STEAP1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0015677	copper ion import
BP	IEA	GO:0055072	iron ion homeostasis
BP	IBA	GO:0055114	oxidation-reduction process
BP	IEA	GO:0055114	oxidation-reduction process
BP	IBA	GO:0098706	ferric iron import across plasma membrane
CC	IBA	GO:0005768	endosome
CC	IBA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0005911	cell-cell junction
CC	IEA	GO:0010008	endosome membrane
CC	HDA	GO:0016020	membrane
MF	TAS	GO:0005215	transporter activity
MF	IBA	GO:0008823	cupric reductase activity
MF	TAS	GO:0015267	channel activity
MF	IEA	GO:0046872	metal ion binding
MF	IBA	GO:0052851	ferric-chelate reductase (NADPH) activity

Gene expression in normal tissue: STEAP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STEAP1

Database	Pathway ID	Pathway Des.
wikipathways	WP3286	Copper homeostasis
kegg	hsa04978	Mineral absorption - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STEAP1

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DATATYPES

CLASSFICATION

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