STEAP1


Summary: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
STEAP family member 1MIM:604415Ensembl:ENSG00000164647HGNC:HGNC:11378PA361937q21.13

GO terms in STEAP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0015677copper ion import
BPIEAGO:0055072iron ion homeostasis
BPIBAGO:0055114oxidation-reduction process
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:0098706ferric iron import across plasma membrane
CCIBAGO:0005768endosome
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0005911cell-cell junction
CCIEAGO:0010008endosome membrane
CCHDAGO:0016020membrane
MFTASGO:0005215transporter activity
MFIBAGO:0008823cupric reductase activity
MFTASGO:0015267channel activity
MFIEAGO:0046872metal ion binding
MFIBAGO:0052851ferric-chelate reductase (NADPH) activity

Gene expression in normal tissue: STEAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STEAP1


DatabasePathway IDPathway Des.
wikipathwaysWP3286Copper homeostasis
kegghsa04978Mineral absorption - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STEAP1

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