ERLEC1


Summary: This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
endoplasmic reticulum lectin 1MIM:611229Ensembl:ENSG00000068912HGNC:HGNC:25222PA1656966362p16.2

GO terms in ERLEC1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIDAGO:0051082unfolded protein binding
BPIBAGO:0030433ubiquitin-dependent ERAD pathway
BPIBAGO:0030970retrograde protein transport, ER to cytosol
BPTASGO:0036503ERAD pathway
BPTASGO:0055085transmembrane transport
BPIMPGO:1904153negative regulation of retrograde protein transport, ER to cytosol
CCIBAGO:0005788endoplasmic reticulum lumen
CCIDAGO:0005788endoplasmic reticulum lumen
CCTASGO:0044322endoplasmic reticulum quality control compartment

Gene expression in normal tissue: ERLEC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERLEC1


DatabasePathway IDPathway Des.
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
reactomeR-HSA-5358346Hedgehog ligand biogenesis
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
reactomeR-HSA-5387390Hh mutants abrogate ligand secretion
reactomeR-HSA-5619084ABC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5678895Defective CFTR causes cystic fibrosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERLEC1

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