ERLEC1
Summary: This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endoplasmic reticulum lectin 1 | MIM:611229 | Ensembl:ENSG00000068912 | HGNC:HGNC:25222 | PA165696636 | 2p16.2 |
GO terms in ERLEC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005515 | protein binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0051082 | unfolded protein binding |
| BP | IBA | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IBA | GO:0030970 | retrograde protein transport, ER to cytosol |
| BP | TAS | GO:0036503 | ERAD pathway |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | IMP | GO:1904153 | negative regulation of retrograde protein transport, ER to cytosol |
| CC | IBA | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0044322 | endoplasmic reticulum quality control compartment |
Gene expression in normal tissue: ERLEC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERLEC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-5358346 | Hedgehog ligand biogenesis |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5362768 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| reactome | R-HSA-5387390 | Hh mutants abrogate ligand secretion |
| reactome | R-HSA-5619084 | ABC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5678895 | Defective CFTR causes cystic fibrosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERLEC1
CLASSFICATION
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