PDCD4
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| programmed cell death 4 | MIM:608610 | Ensembl:ENSG00000150593 | HGNC:HGNC:8763 | PA33113 | 10q25.2 |
GO terms in PDCD4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007569 | cell aging |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043508 | negative regulation of JUN kinase activity |
| BP | NAS | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0050729 | positive regulation of inflammatory response |
| BP | ISS | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development |
| BP | ISS | GO:0071222 | cellular response to lipopolysaccharide |
| BP | ISS | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IMP | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| BP | IMP | GO:1904761 | negative regulation of myofibroblast differentiation |
| BP | IDA | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation |
| BP | IMP | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process |
| BP | IMP | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PDCD4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDCD4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP585 | Interferon type I signaling pathways |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | mtor_4pathway | mTOR signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDCD4
CLASSFICATION
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