PDCD4
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608610 Ensembl IDEnsembl:ENSG00000150593 HGNC IDHGNC:HGNC:8763 PHARMGKB IDPA33113 Map Location10q25.2 | |||||
GO terms in PDCD4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007569 | cell aging |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043508 | negative regulation of JUN kinase activity |
Gene expression in normal tissue: PDCD4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDCD4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP585 | Interferon type I signaling pathways |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDCD4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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