GCLM
Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601176 Ensembl IDEnsembl:ENSG00000023909 HGNC IDHGNC:HGNC:4312 PHARMGKB IDPA28613 Map Location1p22.1 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in GCLM
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004357 | glutamate-cysteine ligase activity |
| MF | IMP | GO:0004357 | glutamate-cysteine ligase activity |
| MF | IBA | GO:0030234 | enzyme regulator activity |
| MF | IPI | GO:0035226 | glutamate-cysteine ligase catalytic subunit binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| BP | IEA | GO:0006534 | cysteine metabolic process |
Gene expression in normal tissue: GCLM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GCLM
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156590 | Glutathione conjugation |
| reactome | R-HSA-174403 | Glutathione synthesis and recycling |
| reactome | R-HSA-211859 | Biological oxidations |
| smpdb | SMP00013 | Cysteine Metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GCLM
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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