STK39
Summary: This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 39 | MIM:607648 | Ensembl:ENSG00000198648 | HGNC:HGNC:17717 | PA38243 | 2q24.3 |
GO terms in STK39
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0016301 | kinase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IMP | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0019898 | extrinsic component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IDA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IMP | GO:0023016 | signal transduction by trans-phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | ISS | GO:0032414 | positive regulation of ion transmembrane transporter activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0036438 | maintenance of lens transparency |
| BP | IEA | GO:0043268 | positive regulation of potassium ion transport |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0050801 | ion homeostasis |
| BP | IC | GO:0071476 | cellular hypotonic response |
| BP | IEA | GO:0090188 | negative regulation of pancreatic juice secretion |
| BP | IDA | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity |
| BP | IDA | GO:1901380 | negative regulation of potassium ion transmembrane transport |
| BP | IDA | GO:1905408 | negative regulation of creatine transmembrane transporter activity |
| BP | IDA | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity |
Gene expression in normal tissue: STK39
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK39
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_TCR | TCR |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD226 | ML006 | 5 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD883 | CIL55A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK39
CLASSFICATION
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