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GNAZ

Summary: The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
G protein subunit alpha z	MIM:139160	Ensembl:ENSG00000128266	HGNC:HGNC:4395	PA28775	22q11.22-q11.23

GO terms in GNAZ

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0001664	G-protein coupled receptor binding
MF	IBA	GO:0003924	GTPase activity
MF	TAS	GO:0003924	GTPase activity
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0005525	GTP binding
MF	IBA	GO:0031683	G-protein beta/gamma-subunit complex binding
MF	IEA	GO:0031821	G-protein coupled serotonin receptor binding
MF	IEA	GO:0046872	metal ion binding
CC	TAS	GO:0005635	nuclear envelope
CC	TAS	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005829	cytosol
CC	IBA	GO:0005834	heterotrimeric G-protein complex
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0030425	dendrite
CC	IEA	GO:0044297	cell body
BP	TAS	GO:0006457	protein folding
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	IBA	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
BP	IEA	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Gene expression in normal tissue: GNAZ

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GNAZ

Database	Pathway ID	Pathway Des.
reactome	R-HSA-111885	Opioid Signalling
reactome	R-HSA-111885	Opioid Signalling
reactome	R-HSA-112040	G-protein mediated events
reactome	R-HSA-112040	G-protein mediated events
reactome	R-HSA-112043	PLC beta mediated events
reactome	R-HSA-112043	PLC beta mediated events
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-202040	G-protein activation
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-390466	Chaperonin-mediated protein folding
reactome	R-HSA-391251	Protein folding
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-418555	G alpha (s) signalling events
reactome	R-HSA-418594	G alpha (i) signalling events
reactome	R-HSA-418594	G alpha (i) signalling events
reactome	R-HSA-418597	G alpha (z) signalling events
reactome	R-HSA-418597	G alpha (z) signalling events
reactome	R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP35	G Protein Signaling Pathways
wikipathways	WP536	Calcium Regulation in the Cardiac Cell
kegg	hsa04730	Long-term depression - Homo sapiens (human)
pid	ar_nongenomic_pathway	Nongenotropic Androgen signaling
pid	cxcr3pathway	CXCR3-mediated signaling events
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	endothelinpathway	Endothelins
pid	er_nongenomic_pathway	Plasma membrane estrogen receptor signaling
pid	hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway
pid	s1p_s1p1_pathway	S1P1 pathway
pid	s1p_s1p2_pathway	S1P2 pathway
pid	s1p_s1p3_pathway	S1P3 pathway
pid	s1p_s1p4_pathway	S1P4 pathway
pid	s1p_s1p5_pathway	S1P5 pathway
pid	thrombin_par1_pathway	PAR1-mediated thrombin signaling events

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GNAZ

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