GPD2

Summary: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameglycerol-3-phosphate dehydrogenase 2
OMIM IDMIM:138430
Ensembl IDEnsembl:ENSG00000115159
HGNC IDHGNC:HGNC:4456
PHARMGKB IDPA28837
Map Location2q24.1

Gene Categories:

DRUGGABLE GENOME

GO terms in GPD2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity
MF IEA GO:0005509 calcium ion binding
MF IEA GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
CC TAS GO:0005743 mitochondrial inner membrane
CC IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex
BP IEA GO:0006094 gluconeogenesis
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Gene expression in normal tissue: GPD2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3

Gene-drug pathway distribution

Protein stability and degradation1ERK MAPK signaling1

Pathways in GPD2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1483166 Synthesis of PA
reactome R-HSA-1483206 Glycerophospholipid biosynthesis
reactome R-HSA-1483257 Phospholipid metabolism
reactome R-HSA-163560 Triglyceride catabolism
reactome R-HSA-556833 Metabolism of lipids
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPD2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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