PPP2R3B
Summary: Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300339 Ensembl IDEnsembl:ENSG00000167393 HGNC IDHGNC:HGNC:13417 PHARMGKB IDPA134878872 Map LocationXp22.33 and Yp11.31 | |||||
GO terms in PPP2R3B
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006470 | protein dephosphorylation |
| BP | ISS | GO:0006470 | protein dephosphorylation |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| CC | IBA | GO:0000159 | protein phosphatase type 2A complex |
| CC | ISS | GO:0000159 | protein phosphatase type 2A complex |
Gene expression in normal tissue: PPP2R3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP2R3B
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69206 | G1/S Transition |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP2R3B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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