SLCO1B3


Summary: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
solute carrier organic anion transporter family member 1B3MIM:605495Ensembl:ENSG00000111700HGNC:HGNC:10961PA3584412p12.2

GO terms in SLCO1B3


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0016323basolateral plasma membrane
BPTASGO:0015711organic anion transport
BPIBAGO:0015721bile acid and bile salt transport
BPTASGO:0015721bile acid and bile salt transport
BPIBAGO:0043252sodium-independent organic anion transport
BPTASGO:0043252sodium-independent organic anion transport
BPIEAGO:0055085transmembrane transport
MFTASGO:0008514organic anion transmembrane transporter activity
MFIBAGO:0015125bile acid transmembrane transporter activity
MFTASGO:0015125bile acid transmembrane transporter activity
MFIBAGO:0015347sodium-independent organic anion transmembrane transporter activity

Gene expression in normal tissue: SLCO1B3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLCO1B3


DatabasePathway IDPathway Des.
smpdbSMP00434Paclitaxel Action Pathway
smpdbSMP00435Docetaxel Action Pathway
smpdbSMP00652Mycophenolic Acid Metabolism Pathway
kegghsa04976Bile secretion - Homo sapiens (human)
pharmgkbPA145011108Statin Pathway - Generalized, Pharmacokinetics
pharmgkbPA145011109Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
pharmgkbPA145011110Pravastatin Pathway, Pharmacokinetics
pharmgkbPA145011111Fluvastatin Pathway, Pharmacokinetics
pharmgkbPA145011112Rosuvastatin Pathway, Pharmacokinetics
pharmgkbPA154426155Taxane Pathway, Pharmacokinetics
pharmgkbPA165816349Methotrexate Pathway, Pharmacokinetics
pharmgkbPA165964832Mycophenolic acid Pathway, Pharmacokinetics
pharmgkbPA166041114Ibuprofen Pathway, Pharmacokinetics
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-159418Recycling of bile acids and salts
reactomeR-HSA-1643685Disease
reactomeR-HSA-194068Bile acid and bile salt metabolism
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425397Transport of vitamins, nucleosides, and related molecules
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5619058Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)
reactomeR-HSA-5619102SLC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-879518Transport of organic anions
reactomeR-HSA-8957322Metabolism of steroids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLCO1B3

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