NPBWR2
Summary: The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neuropeptides B and W receptor 2 | MIM:600731 | Ensembl:ENSG00000125522 | HGNC:HGNC:4530 | PA28923 | 20q13.33 |
GO terms in NPBWR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | IBA | GO:0007218 | neuropeptide signaling pathway |
| BP | IEA | GO:0038003 | opioid receptor signaling pathway |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IC | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043005 | neuron projection |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | TAS | GO:0004985 | opioid receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008188 | neuropeptide receptor activity |
| MF | IBA | GO:0042277 | peptide binding |
| MF | IBA | GO:0042923 | neuropeptide binding |
Gene expression in normal tissue: NPBWR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPBWR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPBWR2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.