NPBWR2


Summary: The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
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HGNC ID
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GO terms in NPBWR2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0007186 G-protein coupled receptor signaling pathway
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
BP IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BP IBA GO:0007218 neuropeptide signaling pathway
BP IEA GO:0038003 opioid receptor signaling pathway
CC TAS GO:0005886 plasma membrane
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Gene expression in normal tissue: NPBWR2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in NPBWR2


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Database
Pathway ID
Pathway Des.
wikipathways WP455 GPCRs, Class A Rhodopsin-like
kegg hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-375276 Peptide ligand-binding receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

KRASKRASZNF273ZNF273PAX5PAX5CCDC117CCDC117SLC16A3SLC16A3NPAS2NPAS2RXRARXRAZFP36L2ZFP36L2RNU2-11PRNU2-11PAPOC1APOC1TCF7L2TCF7L2ZNF682ZNF682BRAFBRAFWDR24WDR24FERMT1FERMT1NHLRC1NHLRC1ZNF736ZNF736RN7SL477PRN7SL477PNRASNRASKLHL32KLHL32PD0325901PD0325901NPBWR2NPBWR2

Gene-drug targets distribution

Gene Structure: PDB

Models in NPBWR2

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Reference ID
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Cancer
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Source
No matching records found

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