KANSL1
Summary: This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612452 Ensembl IDEnsembl:ENSG00000120071 HGNC IDHGNC:HGNC:24565 PHARMGKB IDPA142671604 Map Location17q21.31 | |||||
Gene Categories:
HISTONE MODIFICATIONGO terms in KANSL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0035035 | histone acetyltransferase binding |
| MF | IBA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
| MF | IDA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
| MF | IBA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
| MF | IDA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
Gene expression in normal tissue: KANSL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KANSL1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KANSL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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