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SCAI

Summary: This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
suppressor of cancer cell invasion		Ensembl:ENSG00000173611	HGNC:HGNC:26709	PA165586233	9q33.3

GO terms in SCAI

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0003714	transcription corepressor activity
MF	IMP	GO:0003714	transcription corepressor activity
MF	IPI	GO:0005515	protein binding
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006355	regulation of transcription, DNA-templated
BP	IMP	GO:0030336	negative regulation of cell migration
BP	ISS	GO:0035024	negative regulation of Rho protein signal transduction
BP	IEA	GO:1903507	negative regulation of nucleic acid-templated transcription
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IEA	GO:0016021	integral component of membrane
CC	IDA	GO:0031965	nuclear membrane

Gene expression in normal tissue: SCAI

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCAI

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-5663220	RHO GTPases Activate Formins
pid	rhoa_pathway	RhoA signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCAI

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