Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011].

ankyrin 2MIM:106410Ensembl:ENSG00000145362HGNC:HGNC:493PA247994q25-q26

Gene Categories:


GO terms in ANK2

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0030507spectrin binding
MFISSGO:0030674protein binding, bridging
MFIBAGO:0044325ion channel binding
MFIPIGO:0044325ion channel binding
MFISSGO:0044325ion channel binding
MFISSGO:0051117ATPase binding
BPIMPGO:0002027regulation of heart rate
BPIMPGO:0003283atrial septum development
BPISSGO:0006874cellular calcium ion homeostasis
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIEAGO:0007010cytoskeleton organization
BPIGIGO:0010628positive regulation of gene expression
BPIGIGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
BPISSGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
BPIMPGO:0010882regulation of cardiac muscle contraction by calcium ion signaling
BPIEAGO:0015031protein transport
BPIEAGO:0030913paranodal junction assembly
BPICGO:0031647regulation of protein stability
BPISSGO:0033292T-tubule organization
BPIGIGO:0033365protein localization to organelle
BPISSGO:0034394protein localization to cell surface
BPIGIGO:0034613cellular protein localization
BPISSGO:0036309protein localization to M-band
BPISSGO:0036371protein localization to T-tubule
BPISSGO:0043268positive regulation of potassium ion transport
BPIBAGO:0050808synapse organization
BPISSGO:0050821protein stabilization
BPIGIGO:0051279regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051597response to methylmercury
BPIGIGO:0051924regulation of calcium ion transport
BPISSGO:0051928positive regulation of calcium ion transport
BPIMPGO:0055117regulation of cardiac muscle contraction
BPIMPGO:0060307regulation of ventricular cardiac muscle cell membrane repolarization
BPTASGO:0070296sarcoplasmic reticulum calcium ion transport
BPIGIGO:0070972protein localization to endoplasmic reticulum
BPIBAGO:0072659protein localization to plasma membrane
BPIGIGO:0072659protein localization to plasma membrane
BPISSGO:0072659protein localization to plasma membrane
BPIGIGO:0086004regulation of cardiac muscle cell contraction
BPIMPGO:0086005ventricular cardiac muscle cell action potential
BPIMPGO:0086014atrial cardiac muscle cell action potential
BPISSGO:0086015SA node cell action potential
BPTASGO:0086046membrane depolarization during SA node cell action potential
BPISSGO:0086066atrial cardiac muscle cell to AV node cell communication
BPIMPGO:0086070SA node cell to atrial cardiac muscle cell communication
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPISSGO:0086091regulation of heart rate by cardiac conduction
BPIMPGO:0098907regulation of SA node cell action potential
BPIMPGO:0098910regulation of atrial cardiac muscle cell action potential
BPIBAGO:0099612protein localization to axon
BPISSGO:1901018positive regulation of potassium ion transmembrane transporter activity
BPISSGO:1901019regulation of calcium ion transmembrane transporter activity
BPISSGO:1901021positive regulation of calcium ion transmembrane transporter activity
BPISSGO:2001259positive regulation of cation channel activity
CCIEAGO:0005769early endosome
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCIBAGO:0014704intercalated disc
CCISSGO:0014704intercalated disc
CCIDAGO:0016323basolateral plasma membrane
CCIEAGO:0016324apical plasma membrane
CCISSGO:0030018Z disc
CCISSGO:0031430M band
CCISSGO:0031672A band
CCIBAGO:0033268node of Ranvier
CCIBAGO:0033270paranode region of axon
CCIEAGO:0043005neuron projection
CCIBAGO:0043194axon initial segment
CCIEAGO:0045121membrane raft
CCIEAGO:0045211postsynaptic membrane
CCIEAGO:0055037recycling endosome

Gene expression in normal tissue: ANK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANK2

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANK2