GRIA1
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor AMPA type subunit 1 | MIM:138248 | Ensembl:ENSG00000155511 | HGNC:HGNC:4571 | PA28966 | 5q33.2 |
GO terms in GRIA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001540 | amyloid-beta binding |
| MF | IBA | GO:0004971 | AMPA glutamate receptor activity |
| MF | IDA | GO:0004971 | AMPA glutamate receptor activity |
| MF | TAS | GO:0005231 | excitatory extracellular ligand-gated ion channel activity |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008066 | glutamate receptor activity |
| MF | ISS | GO:0030165 | PDZ domain binding |
| MF | IBA | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| MF | IEA | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| MF | IEA | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007616 | long-term memory |
| BP | IEA | GO:0031623 | receptor internalization |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0060292 | long term synaptic depression |
| BP | IEA | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | ISS | GO:0009986 | cell surface |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030425 | dendrite |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IBA | GO:0032281 | AMPA glutamate receptor complex |
| CC | ISS | GO:0032281 | AMPA glutamate receptor complex |
| CC | IDA | GO:0032591 | dendritic spine membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | IEA | GO:0044308 | axonal spine |
| CC | ISS | GO:0044309 | neuron spine |
| CC | IDA | GO:0055037 | recycling endosome |
| CC | IEA | GO:0055038 | recycling endosome membrane |
| CC | IEA | GO:0098839 | postsynaptic density membrane |
Gene expression in normal tissue: GRIA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
| netpath | Pathway_BDNF | BDNF |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-399710 | Activation of AMPA receptors |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5694530 | Cargo concentration in the ER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-8849932 | Synaptic adhesion-like molecules |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIA1
CLASSFICATION
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