Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].

glutamate ionotropic receptor AMPA type subunit 2MIM:138247Ensembl:ENSG00000120251HGNC:HGNC:4572PA289674q32.1

GO terms in GRIA2

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCTASGO:0009897external side of plasma membrane
CCIEAGO:0030054cell junction
CCTASGO:0030666endocytic vesicle membrane
CCIBAGO:0032281AMPA glutamate receptor complex
CCISSGO:0032281AMPA glutamate receptor complex
CCNASGO:0043197dendritic spine
CCIEAGO:0045211postsynaptic membrane
CCNASGO:0060076excitatory synapse
CCNASGO:0098843postsynaptic endocytic zone
BPTASGO:0007165signal transduction
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0034220ion transmembrane transport
BPIDAGO:0035235ionotropic glutamate receptor signaling pathway
BPTASGO:0035249synaptic transmission, glutamatergic
BPIEAGO:0060079excitatory postsynaptic potential
MFISSGO:0001540amyloid-beta binding
MFNASGO:0001540amyloid-beta binding
MFIDAGO:0004970ionotropic glutamate receptor activity
MFIBAGO:0004971AMPA glutamate receptor activity
MFISSGO:0004971AMPA glutamate receptor activity
MFNASGO:0004971AMPA glutamate receptor activity
MFTASGO:0005231excitatory extracellular ligand-gated ion channel activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: GRIA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIA2

DatabasePathway IDPathway Des.
pidncadherinpathwayN-cadherin signaling events
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-399710Activation of AMPA receptors
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
biocartafosbpathwayfosb gene expression and drug abuse

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIA2