Summary: In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010].

NIN1 (RPN12) binding protein 1 homologMIM:613586Ensembl:ENSG00000141101HGNC:HGNC:29540PA14348558516q22.1

GO terms in NOB1

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006364rRNA processing
BPIEAGO:0007601visual perception
BPIBAGO:0030490maturation of SSU-rRNA
BPIEAGO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic
CCIBAGO:0030688preribosome, small subunit precursor
MFEXPGO:0004521endoribonuclease activity
MFIBAGO:0004521endoribonuclease activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: NOB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NOB1

DatabasePathway IDPathway Des.
kegghsa03008Ribosome biogenesis in eukaryotes - Homo sapiens (human)
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NOB1