NTMT1
Summary: The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| N-terminal Xaa-Pro-Lys N-methyltransferase 1 | MIM:613560 | Ensembl:ENSG00000148335 | HGNC:HGNC:23373 | PA162395788 | 9q34.11 |
Gene Categories:
HISTONE MODIFICATIONGO terms in NTMT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008168 | methyltransferase activity |
| MF | IDA | GO:0008276 | protein methyltransferase activity |
| MF | IDA | GO:0042054 | histone methyltransferase activity |
| MF | IBA | GO:0071885 | N-terminal protein N-methyltransferase activity |
| MF | IDA | GO:0071885 | N-terminal protein N-methyltransferase activity |
| BP | IBA | GO:0006480 | N-terminal protein amino acid methylation |
| BP | IMP | GO:0007051 | spindle organization |
| BP | IMP | GO:0007059 | chromosome segregation |
| BP | IDA | GO:0016571 | histone methylation |
| BP | IBA | GO:0018011 | N-terminal peptidyl-alanine methylation |
| BP | IEA | GO:0018012 | N-terminal peptidyl-alanine trimethylation |
| BP | IDA | GO:0018013 | N-terminal peptidyl-glycine methylation |
| BP | IDA | GO:0018016 | N-terminal peptidyl-proline dimethylation |
| BP | IBA | GO:0035568 | N-terminal peptidyl-proline methylation |
| BP | IBA | GO:0035570 | N-terminal peptidyl-serine methylation |
| BP | IDA | GO:0035572 | N-terminal peptidyl-serine dimethylation |
| BP | IDA | GO:0035573 | N-terminal peptidyl-serine trimethylation |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: NTMT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTMT1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTMT1
CLASSFICATION
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