GRIK3
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor kainate type subunit 3 | MIM:138243 | Ensembl:ENSG00000163873 | HGNC:HGNC:4581 | PA28975 | 1p34.3 |
GO terms in GRIK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway |
| BP | IDA | GO:0007215 | glutamate receptor signaling pathway |
| BP | IDA | GO:0007216 | G-protein coupled glutamate receptor signaling pathway |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IDA | GO:0042391 | regulation of membrane potential |
| BP | ISS | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0050804 | modulation of chemical synaptic transmission |
| BP | ISS | GO:0051967 | negative regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0032839 | dendrite cytoplasm |
| CC | IBA | GO:0032983 | kainate selective glutamate receptor complex |
| CC | IBA | GO:0042734 | presynaptic membrane |
| CC | ISS | GO:0043195 | terminal bouton |
| CC | ISS | GO:0043204 | perikaryon |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| MF | IDA | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity |
| MF | TAS | GO:0001664 | G-protein coupled receptor binding |
| MF | IDA | GO:0004970 | ionotropic glutamate receptor activity |
| MF | ISS | GO:0004970 | ionotropic glutamate receptor activity |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IBA | GO:0008066 | glutamate receptor activity |
| MF | TAS | GO:0008066 | glutamate receptor activity |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015277 | kainate selective glutamate receptor activity |
| MF | IDA | GO:0015277 | kainate selective glutamate receptor activity |
| MF | IBA | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
Gene expression in normal tissue: GRIK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
| reactome | R-HSA-451308 | Activation of Ca-permeable Kainate Receptor |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| reactome | R-HSA-500657 | Presynaptic function of Kainate receptors |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIK3
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