Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008].

glutamate ionotropic receptor kainate type subunit 3MIM:138243Ensembl:ENSG00000163873HGNC:HGNC:4581PA289751p34.3

GO terms in GRIK3

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
BPIDAGO:0007215glutamate receptor signaling pathway
BPIDAGO:0007216G-protein coupled glutamate receptor signaling pathway
BPIEAGO:0034220ion transmembrane transport
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIBAGO:0035249synaptic transmission, glutamatergic
BPIDAGO:0042391regulation of membrane potential
BPISSGO:0042391regulation of membrane potential
BPIBAGO:0050804modulation of chemical synaptic transmission
BPISSGO:0051967negative regulation of synaptic transmission, glutamatergic
BPIEAGO:0060079excitatory postsynaptic potential
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCISSGO:0032839dendrite cytoplasm
CCIBAGO:0032983kainate selective glutamate receptor complex
CCIBAGO:0042734presynaptic membrane
CCISSGO:0043195terminal bouton
CCIBAGO:0045211postsynaptic membrane
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:0098839postsynaptic density membrane
MFIDAGO:0001640adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
MFTASGO:0001664G-protein coupled receptor binding
MFIDAGO:0004970ionotropic glutamate receptor activity
MFISSGO:0004970ionotropic glutamate receptor activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIBAGO:0008066glutamate receptor activity
MFTASGO:0008066glutamate receptor activity
MFTASGO:0015276ligand-gated ion channel activity
MFIBAGO:0015277kainate selective glutamate receptor activity
MFIDAGO:0015277kainate selective glutamate receptor activity
MFIBAGO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gene expression in normal tissue: GRIK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIK3

DatabasePathway IDPathway Des.
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-451306Ionotropic activity of kainate receptors
reactomeR-HSA-451308Activation of Ca-permeable Kainate Receptor
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
reactomeR-HSA-500657Presynaptic function of Kainate receptors

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIK3