GRIK3
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:138243 Ensembl IDEnsembl:ENSG00000163873 HGNC IDHGNC:HGNC:4581 PHARMGKB IDPA28975 Map Location1p34.3 | |||||
GO terms in GRIK3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway |
| BP | IDA | GO:0007215 | glutamate receptor signaling pathway |
| BP | IDA | GO:0007216 | G-protein coupled glutamate receptor signaling pathway |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
Gene expression in normal tissue: GRIK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIK3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIK3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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