Summary: This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].

glutamate ionotropic receptor kainate type subunit 4MIM:600282Ensembl:ENSG00000149403HGNC:HGNC:4582PA2897611q23.3

GO terms in GRIK4

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007215glutamate receptor signaling pathway
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0034220ion transmembrane transport
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIBAGO:0035249synaptic transmission, glutamatergic
BPIBAGO:0050804modulation of chemical synaptic transmission
BPIEAGO:0060079excitatory postsynaptic potential
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIBAGO:0032983kainate selective glutamate receptor complex
CCIEAGO:0032983kainate selective glutamate receptor complex
CCIBAGO:0042734presynaptic membrane
CCIEAGO:0042734presynaptic membrane
CCIBAGO:0045211postsynaptic membrane
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:0098839postsynaptic density membrane
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIBAGO:0008066glutamate receptor activity
MFTASGO:0015276ligand-gated ion channel activity
MFIBAGO:0015277kainate selective glutamate receptor activity
MFTASGO:0015277kainate selective glutamate receptor activity
MFIBAGO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gene expression in normal tissue: GRIK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIK4

DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-451306Ionotropic activity of kainate receptors
reactomeR-HSA-451308Activation of Ca-permeable Kainate Receptor
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIK4