FHOD1
Summary: This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| formin homology 2 domain containing 1 | MIM:606881 | Ensembl:ENSG00000135723 | HGNC:HGNC:17905 | PA28143 | 16q22.1 |
GO terms in FHOD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001725 | stress fiber |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0014704 | intercalated disc |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0032059 | bleb |
| BP | IEA | GO:0007097 | nuclear migration |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0051492 | regulation of stress fiber assembly |
| BP | IDA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IEA | GO:0051660 | establishment of centrosome localization |
| MF | IEA | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IMP | GO:0043621 | protein self-association |
Gene expression in normal tissue: FHOD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FHOD1
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FHOD1
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