Summary: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

CD274 moleculeMIM:605402Ensembl:ENSG00000120217HGNC:HGNC:17635PA1349152809p24.1

GO terms in CD274

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIBAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIDAGO:0031901early endosome membrane
CCIDAGO:0055038recycling endosome membrane
CCIDAGO:0070062extracellular exosome
BPIMPGO:0002845positive regulation of tolerance induction to tumor cell
BPIBAGO:0006955immune response
BPIDAGO:0006955immune response
BPIBAGO:0007165signal transduction
BPIDAGO:0007165signal transduction
BPIBAGO:0007166cell surface receptor signaling pathway
BPIDAGO:0007166cell surface receptor signaling pathway
BPIEAGO:0030335positive regulation of cell migration
BPIBAGO:0031295T cell costimulation
BPIDAGO:0031295T cell costimulation
BPTASGO:0031295T cell costimulation
BPIMPGO:0032689negative regulation of interferon-gamma production
BPIMPGO:0032693negative regulation of interleukin-10 production
BPIDAGO:0034097response to cytokine
BPIBAGO:0042102positive regulation of T cell proliferation
BPTASGO:0042102positive regulation of T cell proliferation
BPIBAGO:0042130negative regulation of T cell proliferation
BPIMPGO:0046006regulation of activated T cell proliferation
BPIMPGO:0046007negative regulation of activated T cell proliferation
BPIMPGO:0070232regulation of T cell apoptotic process
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:1901998toxin transport
BPIMPGO:1903556negative regulation of tumor necrosis factor superfamily cytokine production
BPIDAGO:1905399regulation of activated CD4-positive, alpha-beta T cell apoptotic process
BPIDAGO:1905404positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
BPIDAGO:2001181positive regulation of interleukin-10 secretion
BPIMPGO:2001186negative regulation of CD8-positive, alpha-beta T cell activation

Gene expression in normal tissue: CD274

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD274

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389948PD-1 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD977PDL1 inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD274