CD274
Summary: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD274 molecule | MIM:605402 | Ensembl:ENSG00000120217 | HGNC:HGNC:17635 | PA134915280 | 9p24.1 |
GO terms in CD274
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031901 | early endosome membrane |
| CC | IDA | GO:0055038 | recycling endosome membrane |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | IMP | GO:0002845 | positive regulation of tolerance induction to tumor cell |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0006955 | immune response |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IDA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0031295 | T cell costimulation |
| BP | IDA | GO:0031295 | T cell costimulation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IMP | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IMP | GO:0032693 | negative regulation of interleukin-10 production |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0042102 | positive regulation of T cell proliferation |
| BP | TAS | GO:0042102 | positive regulation of T cell proliferation |
| BP | IBA | GO:0042130 | negative regulation of T cell proliferation |
| BP | IMP | GO:0046006 | regulation of activated T cell proliferation |
| BP | IMP | GO:0046007 | negative regulation of activated T cell proliferation |
| BP | IMP | GO:0070232 | regulation of T cell apoptotic process |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:1901998 | toxin transport |
| BP | IMP | GO:1903556 | negative regulation of tumor necrosis factor superfamily cytokine production |
| BP | IDA | GO:1905399 | regulation of activated CD4-positive, alpha-beta T cell apoptotic process |
| BP | IDA | GO:1905404 | positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process |
| BP | IDA | GO:2001181 | positive regulation of interleukin-10 secretion |
| BP | IMP | GO:2001186 | negative regulation of CD8-positive, alpha-beta T cell activation |
Gene expression in normal tissue: CD274
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD274
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389948 | PD-1 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD978 | Pembrolizumab | 6 |
| iGMDRD824 | Atezolizumab | 8 |
| iGMDRD830 | Avelumab | 1 |
| iGMDRD508 | KU0063794 | 1 |
| iGMDRD929 | Ipilimumab | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD955 | Nivolumab | 6 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD977 | PDL1 inhibitor | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD274
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