GRM4


Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].

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GO terms in GRM4


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005622 intracellular
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IDA GO:0005887 integral component of plasma membrane
CC IDA GO:0031410 cytoplasmic vesicle
CC IBA GO:0042734 presynaptic membrane
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Gene expression in normal tissue: GRM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRM4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-418594 G alpha (i) signalling events
reactome R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
reactome R-HSA-500792 GPCR ligand binding
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRM4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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