GSN
Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gelsolin | MIM:137350 | Ensembl:ENSG00000148180 | HGNC:HGNC:4620 | PA29011 | 9q33.2 |
GO terms in GSN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006911 | phagocytosis, engulfment |
| BP | IEA | GO:0007568 | aging |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0014003 | oligodendrocyte development |
| BP | IMP | GO:0014891 | striated muscle atrophy |
| BP | IMP | GO:0022617 | extracellular matrix disassembly |
| BP | IDA | GO:0030041 | actin filament polymerization |
| BP | IMP | GO:0030041 | actin filament polymerization |
| BP | ISS | GO:0030041 | actin filament polymerization |
| BP | IEA | GO:0030155 | regulation of cell adhesion |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | IEA | GO:0042246 | tissue regeneration |
| BP | IMP | GO:0042989 | sequestering of actin monomers |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045010 | actin nucleation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IMP | GO:0046597 | negative regulation of viral entry into host cell |
| BP | IEA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IDA | GO:0051014 | actin filament severing |
| BP | IMP | GO:0051014 | actin filament severing |
| BP | ISS | GO:0051014 | actin filament severing |
| BP | IEA | GO:0051016 | barbed-end actin filament capping |
| BP | IMP | GO:0051127 | positive regulation of actin nucleation |
| BP | IEA | GO:0051593 | response to folic acid |
| BP | IMP | GO:0051693 | actin filament capping |
| BP | ISS | GO:0051693 | actin filament capping |
| BP | IMP | GO:0060271 | cilium assembly |
| BP | IEA | GO:0071276 | cellular response to cadmium ion |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| BP | IMP | GO:0071801 | regulation of podosome assembly |
| BP | IGI | GO:0090527 | actin filament reorganization |
| BP | IMP | GO:0097017 | renal protein absorption |
| BP | IMP | GO:0097284 | hepatocyte apoptotic process |
| BP | IMP | GO:1902174 | positive regulation of keratinocyte apoptotic process |
| BP | IMP | GO:1903903 | regulation of establishment of T cell polarity |
| BP | IMP | GO:1903906 | regulation of plasma membrane raft polarization |
| BP | IMP | GO:1903909 | regulation of receptor clustering |
| BP | ISS | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| BP | IMP | GO:1990000 | amyloid fibril formation |
| BP | IMP | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| CC | IEA | GO:0001726 | ruffle |
| CC | IDA | GO:0002102 | podosome |
| CC | HDA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005576 | extracellular region |
| CC | ISS | GO:0005576 | extracellular region |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0016528 | sarcoplasm |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030478 | actin cap |
| CC | IDA | GO:0030864 | cortical actin cytoskeleton |
| CC | IDA | GO:0030864 | cortical actin cytoskeleton |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | IEA | GO:0045335 | phagocytic vesicle |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| MF | IDA | GO:0003779 | actin binding |
| MF | IMP | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0045159 | myosin II binding |
| MF | IEA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: GSN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | ncadherinpathway | N-cadherin signaling events |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | rhopathway | rho cell motility signaling pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-977225 | Amyloid fiber formation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSN
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.