GSN

Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namegelsolin
OMIM IDMIM:137350
Ensembl IDEnsembl:ENSG00000148180
HGNC IDHGNC:HGNC:4620
PHARMGKB IDPA29011
Map Location9q33.2

Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in GSN


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0006911 phagocytosis, engulfment
BP IEA GO:0007568 aging
BP IMP GO:0010628 positive regulation of gene expression
BP IEA GO:0014003 oligodendrocyte development
BP IMP GO:0014891 striated muscle atrophy
BP IMP GO:0022617 extracellular matrix disassembly
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Gene expression in normal tissue: GSN

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in GSN


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Database
Pathway ID
Pathway Des.
wikipathways WP51 Regulation of Actin Cytoskeleton
wikipathways WP615 Senescence and Autophagy in Cancer
pid ar_pathway Coregulation of Androgen receptor activity
pid avb3_opn_pathway Osteopontin-mediated events
pid caspase_pathway Caspase Cascade in Apoptosis
pid ncadherinpathway N-cadherin signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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