GSN
Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
gelsolin | MIM:137350 | Ensembl:ENSG00000148180 | HGNC:HGNC:4620 | PA29011 | 9q33.2 |
GO terms in GSN
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0006911 | phagocytosis, engulfment |
BP | IEA | GO:0007568 | aging |
BP | IMP | GO:0010628 | positive regulation of gene expression |
BP | IEA | GO:0014003 | oligodendrocyte development |
BP | IMP | GO:0014891 | striated muscle atrophy |
BP | IMP | GO:0022617 | extracellular matrix disassembly |
BP | IDA | GO:0030041 | actin filament polymerization |
BP | IMP | GO:0030041 | actin filament polymerization |
BP | ISS | GO:0030041 | actin filament polymerization |
BP | IEA | GO:0030155 | regulation of cell adhesion |
BP | IMP | GO:0031648 | protein destabilization |
BP | IEA | GO:0042246 | tissue regeneration |
BP | IMP | GO:0042989 | sequestering of actin monomers |
BP | TAS | GO:0043312 | neutrophil degranulation |
BP | TAS | GO:0044267 | cellular protein metabolic process |
BP | IEA | GO:0045010 | actin nucleation |
BP | IEA | GO:0045471 | response to ethanol |
BP | IMP | GO:0046597 | negative regulation of viral entry into host cell |
BP | IEA | GO:0048015 | phosphatidylinositol-mediated signaling |
BP | IDA | GO:0051014 | actin filament severing |
BP | IMP | GO:0051014 | actin filament severing |
BP | ISS | GO:0051014 | actin filament severing |
BP | IEA | GO:0051016 | barbed-end actin filament capping |
BP | IMP | GO:0051127 | positive regulation of actin nucleation |
BP | IEA | GO:0051593 | response to folic acid |
BP | IMP | GO:0051693 | actin filament capping |
BP | ISS | GO:0051693 | actin filament capping |
BP | IMP | GO:0060271 | cilium assembly |
BP | IEA | GO:0071276 | cellular response to cadmium ion |
BP | IEA | GO:0071346 | cellular response to interferon-gamma |
BP | IMP | GO:0071801 | regulation of podosome assembly |
BP | IGI | GO:0090527 | actin filament reorganization |
BP | IMP | GO:0097017 | renal protein absorption |
BP | IMP | GO:0097284 | hepatocyte apoptotic process |
BP | IMP | GO:1902174 | positive regulation of keratinocyte apoptotic process |
BP | IMP | GO:1903903 | regulation of establishment of T cell polarity |
BP | IMP | GO:1903906 | regulation of plasma membrane raft polarization |
BP | IMP | GO:1903909 | regulation of receptor clustering |
BP | ISS | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
BP | IMP | GO:1990000 | amyloid fibril formation |
BP | IMP | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
CC | IEA | GO:0001726 | ruffle |
CC | IDA | GO:0002102 | podosome |
CC | HDA | GO:0005576 | extracellular region |
CC | IDA | GO:0005576 | extracellular region |
CC | ISS | GO:0005576 | extracellular region |
CC | NAS | GO:0005576 | extracellular region |
CC | TAS | GO:0005576 | extracellular region |
CC | IDA | GO:0005615 | extracellular space |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | ISS | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005886 | plasma membrane |
CC | HDA | GO:0005925 | focal adhesion |
CC | TAS | GO:0015629 | actin cytoskeleton |
CC | IDA | GO:0016528 | sarcoplasm |
CC | IEA | GO:0030027 | lamellipodium |
CC | IDA | GO:0030478 | actin cap |
CC | IDA | GO:0030864 | cortical actin cytoskeleton |
CC | IDA | GO:0030864 | cortical actin cytoskeleton |
CC | TAS | GO:0034774 | secretory granule lumen |
CC | IEA | GO:0043209 | myelin sheath |
CC | IEA | GO:0045335 | phagocytic vesicle |
CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
CC | HDA | GO:0070062 | extracellular exosome |
CC | HDA | GO:0072562 | blood microparticle |
CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
MF | IDA | GO:0003779 | actin binding |
MF | IMP | GO:0005509 | calcium ion binding |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0045159 | myosin II binding |
MF | IEA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: GSN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSN
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP51 | Regulation of Actin Cytoskeleton |
wikipathways | WP615 | Senescence and Autophagy in Cancer |
pid | ar_pathway | Coregulation of Androgen receptor activity |
pid | avb3_opn_pathway | Osteopontin-mediated events |
pid | caspase_pathway | Caspase Cascade in Apoptosis |
pid | ncadherinpathway | N-cadherin signaling events |
netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
netpath | Pathway_EGFR1 | EGFR1 |
kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
biocarta | rhopathway | rho cell motility signaling pathway |
reactome | R-HSA-109581 | Apoptosis |
reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-5357801 | Programmed Cell Death |
reactome | R-HSA-6798695 | Neutrophil degranulation |
reactome | R-HSA-75153 | Apoptotic execution phase |
reactome | R-HSA-977225 | Amyloid fiber formation |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in GSN