GSTP1
Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutathione S-transferase pi 1 | MIM:134660 | Ensembl:ENSG00000084207 | HGNC:HGNC:4638 | PA29028 | 11q13.2 |
GO terms in GSTP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004602 | glutathione peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | ISS | GO:0008432 | JUN kinase binding |
| MF | ISS | GO:0019207 | kinase regulator activity |
| MF | IDA | GO:0035730 | S-nitrosoglutathione binding |
| MF | IDA | GO:0035731 | dinitrosyl-iron complex binding |
| MF | IEA | GO:0043295 | glutathione binding |
| MF | NAS | GO:0070026 | nitric oxide binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005622 | intracellular |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097057 | TRAF2-GSTP1 complex |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | ISS | GO:0000302 | response to reactive oxygen species |
| BP | NAS | GO:0002674 | negative regulation of acute inflammatory response |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0006749 | glutathione metabolic process |
| BP | IDA | GO:0006805 | xenobiotic metabolic process |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IDA | GO:0009890 | negative regulation of biosynthetic process |
| BP | IC | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0014003 | oligodendrocyte development |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IDA | GO:0032691 | negative regulation of interleukin-1 beta production |
| BP | IDA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0032872 | regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0032930 | positive regulation of superoxide anion generation |
| BP | IEA | GO:0033591 | response to L-ascorbic acid |
| BP | ISS | GO:0035726 | common myeloid progenitor cell proliferation |
| BP | NAS | GO:0035732 | nitric oxide storage |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | NAS | GO:0043409 | negative regulation of MAPK cascade |
| BP | IDA | GO:0043508 | negative regulation of JUN kinase activity |
| BP | IDA | GO:0043651 | linoleic acid metabolic process |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | ISS | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | IDA | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process |
| BP | ISS | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070664 | negative regulation of leukocyte proliferation |
| BP | ISS | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IEA | GO:0071460 | cellular response to cell-matrix adhesion |
| BP | IDA | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production |
| BP | IEA | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | TAS | GO:1901687 | glutathione derivative biosynthetic process |
| BP | IEA | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| BP | IDA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
Gene expression in normal tissue: GSTP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSTP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
| wikipathways | WP678 | Arachidonate Epoxygenase - Epoxide Hydrolase |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| humancyc | PWY-4061 | glutathione-mediated detoxification |
| humancyc | PWY-7112 | 4-hydroxy-2-nonenal detoxification |
| pharmgkb | PA150642262 | Platinum Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA2025 | Etoposide Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2038 | Ifosfamide Pathway, Pharmacodynamics |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| biocarta | mrppathway | multi-drug resistance factors |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156590 | Glutathione conjugation |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD729 | Folfox protocol | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD288 | Carboplatin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSTP1
CLASSFICATION
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