GSTP1
Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:134660 Ensembl IDEnsembl:ENSG00000084207 HGNC IDHGNC:HGNC:4638 PHARMGKB IDPA29028 Map Location11q13.2 | |||||
GO terms in GSTP1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004602 | glutathione peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | ISS | GO:0008432 | JUN kinase binding |
Gene expression in normal tissue: GSTP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSTP1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
| wikipathways | WP678 | Arachidonate Epoxygenase - Epoxide Hydrolase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSTP1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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