SENP1
Summary: This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612157 Ensembl IDEnsembl:ENSG00000079387 HGNC IDHGNC:HGNC:17927 PHARMGKB IDPA134947038 Map Location12q13.11 | |||||
GO terms in SENP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0031965 | nuclear membrane |
Gene expression in normal tissue: SENP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SENP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3065679 | SUMO is proteolytically processed |
| reactome | R-HSA-3215018 | Processing and activation of SUMO |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SENP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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