SEARCH

HOME / SEARCH / GYPA

GYPA

Summary: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
glycophorin A (MNS blood group)	MIM:617922	Ensembl:ENSG00000170180	HGNC:HGNC:4702	PA29080	4q31.21

Gene Categories:

DRUGGABLE GENOME

GO terms in GYPA

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005886	plasma membrane
CC	TAS	GO:0016020	membrane
CC	IEA	GO:0016021	integral component of membrane
BP	IEA	GO:0046718	viral entry into host cell
BP	TAS	GO:0050900	leukocyte migration
MF	IEA	GO:0001618	virus receptor activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0042802	identical protein binding

Gene expression in normal tissue: GYPA

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GYPA

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
wikipathways	WP2849	Hematopoietic Stem Cell Differentiation
kegg	hsa04640	Hematopoietic cell lineage - Homo sapiens (human)
kegg	hsa05144	Malaria - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GYPA

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.