GYPA


Summary: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].

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Name
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Gene Categories:

DRUGGABLE GENOME

GO terms in GYPA


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC TAS GO:0016020 membrane
CC IEA GO:0016021 integral component of membrane
BP IEA GO:0046718 viral entry into host cell
BP TAS GO:0050900 leukocyte migration
MF IEA GO:0001618 virus receptor activity
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Gene expression in normal tissue: GYPA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GYPA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-202733 Cell surface interactions at the vascular wall
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
kegg hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
kegg hsa05144 Malaria - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GYPA

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Model
Level
Reference ID
Tissue
Cancer
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Clinical Response
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