GYPA
Summary: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:617922 Ensembl IDEnsembl:ENSG00000170180 HGNC IDHGNC:HGNC:4702 PHARMGKB IDPA29080 Map Location4q31.21 |
Gene Categories:
DRUGGABLE GENOMEGO terms in GYPA
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0016020 | membrane |
CC | IEA | GO:0016021 | integral component of membrane |
BP | IEA | GO:0046718 | viral entry into host cell |
BP | TAS | GO:0050900 | leukocyte migration |
MF | IEA | GO:0001618 | virus receptor activity |
Gene expression in normal tissue: GYPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GYPA
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
kegg | hsa05144 | Malaria - Homo sapiens (human) |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in GYPA
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |