OSGIN1
Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607975 Ensembl IDEnsembl:ENSG00000140961 HGNC IDHGNC:HGNC:30093 PHARMGKB IDPA162398489 Map Location16q23.3 | |||||
Gene Categories:
GROWTH FACTORGO terms in OSGIN1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030308 | negative regulation of cell growth |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
Gene expression in normal tissue: OSGIN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OSGIN1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OSGIN1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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