UBQLN2
Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquilin 2 | MIM:300264 | Ensembl:ENSG00000188021 | HGNC:HGNC:12509 | PA37156 | Xp11.21 |
GO terms in UBQLN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006914 | autophagy |
| BP | IMP | GO:0016241 | regulation of macroautophagy |
| BP | IMP | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IMP | GO:1900186 | negative regulation of clathrin-dependent endocytosis |
| BP | IMP | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:1904021 | negative regulation of G-protein coupled receptor internalization |
| BP | IMP | GO:2000785 | regulation of autophagosome assembly |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005776 | autophagosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: UBQLN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBQLN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBQLN2
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