SH3KBP1
Summary: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SH3 domain containing kinase binding protein 1 | MIM:300374 | Ensembl:ENSG00000147010 | HGNC:HGNC:13867 | PA37822 | Xp22.12 |
GO terms in SH3KBP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006897 | endocytosis |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0007010 | cytoskeleton organization |
| BP | NAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0016477 | cell migration |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0061024 | membrane organization |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0030139 | endocytic vesicle |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IEA | GO:0045202 | synapse |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
Gene expression in normal tissue: SH3KBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SH3KBP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8866376 | Reelin signalling pathway |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_KitReceptor | KitReceptor |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SH3KBP1
CLASSFICATION
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