SH3KBP1
Summary: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300374 Ensembl IDEnsembl:ENSG00000147010 HGNC IDHGNC:HGNC:13867 PHARMGKB IDPA37822 Map LocationXp22.12 | |||||
GO terms in SH3KBP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006897 | endocytosis |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0007010 | cytoskeleton organization |
| BP | NAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IMP | GO:0008360 | regulation of cell shape |
Gene expression in normal tissue: SH3KBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SH3KBP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SH3KBP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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