ANXA1

Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameannexin A1
OMIM IDMIM:151690
Ensembl IDEnsembl:ENSG00000135046
HGNC IDHGNC:HGNC:533
PHARMGKB IDPA24823
Map Location9q21.13

GO terms in ANXA1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003697 single-stranded DNA binding
MF IEA GO:0003727 single-stranded RNA binding
MF TAS GO:0005102 signaling receptor binding
MF IDA GO:0005198 structural molecule activity
MF ISS GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: ANXA1

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Pathways in ANXA1


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
wikipathways WP1984 Integrated Breast Cancer Pathway
wikipathways WP2431 Spinal Cord Injury
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP4066 Interleukin-4 and 13 signaling
wikipathways WP98 Prostaglandin Synthesis and Regulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD1020 Trastuzumab 2
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANXA1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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