ANXA1


Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
annexin A1MIM:151690Ensembl:ENSG00000135046HGNC:HGNC:533PA248239q21.13

GO terms in ANXA1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003697single-stranded DNA binding
MFIEAGO:0003727single-stranded RNA binding
MFTASGO:0005102signaling receptor binding
MFIDAGO:0005198structural molecule activity
MFISSGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFTASGO:0005543phospholipid binding
MFIDAGO:0005544calcium-dependent phospholipid binding
MFIDAGO:0019834phospholipase A2 inhibitor activity
MFIDAGO:0030674protein binding, bridging
MFIEAGO:0033676double-stranded DNA-dependent ATPase activity
MFIEAGO:0042803protein homodimerization activity
MFIPIGO:0048306calcium-dependent protein binding
MFHDAGO:0098641cadherin binding involved in cell-cell adhesion
MFIEAGO:1990814DNA/DNA annealing activity
CCIDAGO:0001533cornified envelope
CCIEAGO:0001891phagocytic cup
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005768endosome
CCIDAGO:0005829cytosol
CCIDAGO:0005884actin filament
CCIDAGO:0005886plasma membrane
CCHDAGO:0005913cell-cell adherens junction
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCIEAGO:0016323basolateral plasma membrane
CCISSGO:0016324apical plasma membrane
CCISSGO:0016328lateral plasma membrane
CCIDAGO:0019898extrinsic component of membrane
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0031232extrinsic component of external side of plasma membrane
CCISSGO:0031313extrinsic component of endosome membrane
CCISSGO:0031514motile cilium
CCISSGO:0031901early endosome membrane
CCIEAGO:0031966mitochondrial membrane
CCHDAGO:0031982vesicle
CCIEAGO:0032991protein-containing complex
CCIEAGO:0042383sarcolemma
CCIEAGO:0042629mast cell granule
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070062extracellular exosome
BPIMPGO:0001780neutrophil homeostasis
BPIEAGO:0002250adaptive immune response
BPIDAGO:0002548monocyte chemotaxis
BPISSGO:0002685regulation of leukocyte migration
BPISSGO:0006909phagocytosis
BPISSGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIMPGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIDAGO:0008360regulation of cell shape
BPIEAGO:0010165response to X-ray
BPIEAGO:0014839myoblast migration involved in skeletal muscle regeneration
BPIDAGO:0018149peptide cross-linking
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030073insulin secretion
BPIDAGO:0030216keratinocyte differentiation
BPIEAGO:0030850prostate gland development
BPIEAGO:0031018endocrine pancreas development
BPIDAGO:0031340positive regulation of vesicle fusion
BPIEAGO:0031394positive regulation of prostaglandin biosynthetic process
BPIDAGO:0031532actin cytoskeleton reorganization
BPIEAGO:0032355response to estradiol
BPIEAGO:0032508DNA duplex unwinding
BPISSGO:0032652regulation of interleukin-1 production
BPIDAGO:0032743positive regulation of interleukin-2 production
BPIEAGO:0033031positive regulation of neutrophil apoptotic process
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIEAGO:0042063gliogenesis
BPIDAGO:0042102positive regulation of T cell proliferation
BPTASGO:0043066negative regulation of apoptotic process
BPIEAGO:0043434response to peptide hormone
BPIEAGO:0044849estrous cycle
BPIEAGO:0045087innate immune response
BPIDAGO:0045627positive regulation of T-helper 1 cell differentiation
BPIDAGO:0045629negative regulation of T-helper 2 cell differentiation
BPIMPGO:0045920negative regulation of exocytosis
BPISSGO:0046632alpha-beta T cell differentiation
BPIMPGO:0046883regulation of hormone secretion
BPIEAGO:0050482arachidonic acid secretion
BPISSGO:0050727regulation of inflammatory response
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIEAGO:0070365hepatocyte differentiation
BPIEAGO:0070459prolactin secretion
BPIEAGO:0070555response to interleukin-1
BPIDAGO:0071385cellular response to glucocorticoid stimulus
BPIDAGO:0071621granulocyte chemotaxis
BPIDAGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIDAGO:0090303positive regulation of wound healing
BPIMPGO:0097350neutrophil clearance
BPIEAGO:0098609cell-cell adhesion
BPIEAGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIEAGO:1900138negative regulation of phospholipase A2 activity
BPIMPGO:2000483negative regulation of interleukin-8 secretion

Gene expression in normal tissue: ANXA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANXA1


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP98Prostaglandin Synthesis and Regulation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-444473Formyl peptide receptors bind formyl peptides and many other ligands
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
biocartagcrpathwaycorticosteroids and cardioprotection

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1020Trastuzumab2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANXA1

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